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Dispelling myths about Gram negative mastitis

July 07, 2013
POSTED BY: Roger Saltman | DVM, MBA | Group Director | Cattle and Equine Technical Services | Zoetis

Myth: Antibiotic treatment is not effective against Gram negative mastitis.

Reality: A study from Cornell University reveals mild and moderate cases of Gram negative mastitis are indeed treatable and might not cure without treatment.

In the past, dairy producers have tended to believe that antibiotic treatment is not effective for clinical coliform mastitis infections. But a groundbreaking Cornell University study is the first to show a significant improvement in mild or moderate Gram negative mastitis infections as a result of specific antibiotic therapy.

Highlights from the study:1 

  • Extended duration of therapy makes the difference: Five-day treatment with SPECTRAMAST® LC (ceftiofur hydrochloride) Sterile Suspension resulted in an 89 percent bacteriological, or complete, cure rate in mild or moderate mastitis caused by
    Escherichia coli (E. coli) compared with a cure rate of 53 percent for untreated controls.
  • More milk: Cows that were completely cured gave 8.8 more pounds of milk on the second test day when compared with cows that were not cured. (P<0.05)

Learn more about the research in this video and hear the lead researcher, Ynte Schukken, DVM, Cornell University, discuss what the study means for treatment protocols, including the importance of culturing.

IMPORTANT SAFETY INFORMATION: People with known hypersensitivity to penicillin or cephalosporins should avoid exposure to SPECTRAMAST LC. Product requires a 72-hour milk discard period and a 2 day pre-slaughter withdrawal period following the last treatment. Use of this product in a manner other than indicated on the label, or failure to adhere to proper milk discard period, will result in violative residues. See full Prescribing Information, here.

1 Schukken YH, Bennett GJ, Zurakowski MJ, et al. Randomized clinical trial to evaluate the efficacy of a 5-day ceftiofur hydrochloride intramammary treatment on nonsevere gram-negative clinical mastitis. J Dairy Sci 2011;94(12):6203-6215.


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