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LUTALYSE® HighCon: A new management tool for added reproductive efficiency

November 24, 2015
POSTED BY: Richard Wallace | DVM, MS | Managing Veterinarian | Dairy Technical Services | Zoetis

Zoetis announced the introduction of LUTALYSE® HighCon Injection (dinoprost tromethamine injection), a high-concentration formula of the proven LUTALYSE® Injection (dinoprost tromethamine injection) approved for use in dairy and beef cattle.

We heard producers’ and veterinarians’ requests for improved convenience and flexibility, so we committed to developing a new, relevant, on-label reproductive option. LUTALYSE HighCon delivers the same benefits of LUTALYSE but with some distinguishable improvements:

  • High-concentration formulation 

The higher concentration of LUTALYSE HighCon allows for a 2-mL dose for more convenient administration. More doses per bottle mean fewer bottle changes, too.

  • Subcutaneous administration option

LUTALYSE HighCon is the first and only prostaglandin on the market approved by the Food and Drug Administration for subcutaneous administration in addition to intramuscular administration. This approval gives producers and veterinarians flexible administration options while allowing them to abide by strict Beef Quality Assurance and Dairy Animal Care and Quality Assurance standards and minimize injection site blemishes. According to a 2007 National Market Cow and Bull Beef Quality Audit, dairy cattle had more visible injection site blemishes than beef cows.1 When the economic losses of quality defects in beef from dairy market cattle are added together, the impact translates to an average loss for all dairy producers of $70 to $100 for every market dairy cow sold.2

  • Larger vials

To fit varying herd management needs, LUTALYSE HighCon is available in three vial sizes — 20 mL, 100 mL and 250 mL. The largest size, 250 mL, allows for the maximum number of doses (125) in one bottle and therefore requires fewer bottles to carry when administering to larger groups of cattle.

Note that LUTALYSE HighCon is approved for use in cattle only, not for equine or swine like LUTALYSE

Approved for use with FACTREL® Injection (gonadorelin injection) for FTAI

Like LUTALYSE, LUTALYSE HighCon is approved for use with FACTREL to synchronize estrous cycles to allow for fixed-time artificial insemination in lactating dairy cows to achieve higher pregnancy rates and increased milk production. It also gives producers the flexibility to implement many of the popular synchronization programs recommended by the Dairy Cattle Reproduction Council.

Both LUTALYSE and LUTALYSE® HighCon will remain available to give dairy producers and veterinarians options for what works best for their operations.


IMPORTANT SAFETY INFORMATION FOR LUTALYSE/LUTALYSE HIGHCON: Women of childbearing age and persons with respiratory problems should exercise extreme caution when handling LUTALYSE/LUTALYSE HighCon. LUTALYSE/LUTALYSE HighCon is readily absorbed through the skin and may cause abortion and/or bronchiospasms, therefore spillage on the skin should be washed off immediately with soap and water. Aseptic technique should be used to reduce the possibility of post-injection clostridial infections. Do not administer LUTALYSE/LUTALYSE HighCon in pregnant cattle unless cessation of pregnancy is desired. See full Prescribing Information for LUTALYSE. See full Prescribing Information for LUTALYSE HighCon.

IMPORTANT SAFETY INFORMATION FACTREL: FACTREL is for use in cattle only. See full Prescribing Information.

1 National Cattlemen’s Beef Association. Executive Summary of the 2007 National Market Cow and Bull Beef Quality Audit. Available at: Published December 2007. Accessed October 13, 2015.

2 National Dairy Herd Information Association. Dairy Animal Care & Quality Assurance. Available at: Accessed October 13, 2015.

3 Kalantari AS, Giordano J, Cabrera VE. Wisconsin-Cornell Dairy Repro: A Reproductive Program’s Economic Analysis Tool. Available at: Accessed October 13, 2015.

4 Kalantari AS, Giordano J, Cabrera VE. Evaluating the Economic Value of Changing the Reproductive Management Program for a Specific Dairy Farm. Extension. January 30, 2014.





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