Treat metritis with two shots and zero  milk withdrawal.
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June 15, 2018
POSTED BY: Doug Hammon | DVM, PhD | Managing Veterinarian | Dairy Technical Services | Zoetis

Take quick action to get cows back to full health and peak production after your veterinarian has confirmed a metritis diagnosis. And quick action can come in only two shots and zero milk discard. 

EXCEDE® (ceftiofur crystalline free acid) Sterile Suspension is approved to treat acute postpartum metritis in a two-dose regimen. The protocol for the two-dose treatment of EXCEDE begins with the first dose administered at the base of one ear. Then, 72 hours later, another dose is administered at the base of the opposite ear.

This two-dose treatment is efficacious, cost-effective and likely more convenient than daily metritis treatments.

  • In a field research trial conducted on 15 large dairies, 74.3% of cows with acute metritis were cured after being treated with two doses of EXCEDE.1
  • EXCEDE has zero milk discard, which means the treated cow doesn’t need to be moved to a hospital or treated pen. This not only saves time and labor but also is beneficial to the cow, according to the University of Wisconsin-Madison.2
  • EXCEDE also is backed by the Residue Free Guarantee,* providing peace of mind that you won’t have a violative drug residue as long as you follow the labeled directions and the meat withdrawal time.

For more information on EXCEDE, visit or contact your veterinarian or Zoetis representative.

IMPORTANT SAFETY INFORMATION: People with known hypersensitivity to penicillin or cephalosporins should avoid exposure to EXCEDE. EXCEDE is contraindicated in animals with known allergy to ceftiofur or to the ß-lactam group (penicillins and cephalosporins) of antimicrobials. Inadvertent intra-arterial injection is possible and fatal. Do not use in calves to be processed for veal. Pre-slaughter withdrawal time is 13 days following the last dose. See full Prescribing Information.

*Residue Free Guarantee: If you use a Zoetis-branded ceftiofur product according to label indications, and experience a violative ceftiofur milk or meat residue, Zoetis will compensate you for the beef market value of the animal or purchase the tanker of milk at fair market value. You must purchase the product from a Zoetis-approved supplier, use the product according to label indications, have documentation of the product purchase and treatment records, and have conducted training on appropriate use to ensure proper dose and route of administration of the product. Extra-label use as prescribed by a veterinarian is excluded from the guarantee. If you experience a ceftiofur residue violation after following label indications and the above steps, contact Zoetis Veterinary Medical Information and Product Support (VMIPS) at 800-366-5288 to report the situation.


1 Data on file, Study Report No. 1133C-60-06-509, Zoetis Inc.

2 Nordlund K. Five Key Factors that Determine the Success of Transition Cow Management Programs, in Proceedings. 46th Florida Dairy Prod Conf; 2009.



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